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Minimal (1)disulfiram raises toxicity of metronidazole topical by decreasing metabolism. Small/Importance Unknown. Increased CNS & cardiac toxicity with oral metronidazole and disulfiram; less likely to come about with topical administration because of small absorption.
If sizeable irritation develops from using this medication, discontinue use and consult your doctor.
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METROGEL-VAGINAL is the intravaginal dosage form of the synthetic antibacterial agent, metronidazole, USP in a concentration of 0.75%. Metronidazole is often a member on the imidazole class of antibacterial agents and is classed therapeutically as an antiprotozoal and antibacterial agent.
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Knowledge from well-managed trials straight comparing metronidazole administered orally to metronidazole administered vaginally are certainly not available.
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